Publications

Sara L Dominguez, Benjamin I Laufer, Arundhati Sengupta Ghosh, Qingling Li, Gaia Ruggeri, Maheswara Reddy Emani, Lilian Phu, Brad A Friedman, Wendy Sandoval, Christopher M Rose, Hai Ngu, Oded Foreman, Mike Reichelt, Yves Juste, Guita Lalehzadeh, Dennis Hansen, Helle Nymark, Denia Mellal, Helene Gylling, Łukasz J Kiełpiŉski, Ben Chih, Baris Bingol, Casper C Hoogenraad, William J Meilandt, Amy Easton (2023). TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models. iScience.

Amy E. Byrnes, Sara L. Dominguez, Chun-Wan Yen, Benjamin I. Laufer, Oded Foreman, Mike Reichelt, Han Lin, Meredith Sagolla, Kathy Hötzel, Hai Ngu, Christoffer Soendergaard, Alberto Estevez, Hsiu-Chao Lin, Alexandre Goyon, Juan Bian, Jessica Lin, Flora I. Hinz, Brad A. Friedman, Amy Easton, Casper C. Hoogenraad (2023). Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection. Molecular Therapy — Nucleic Acids.

Min Jung, Michelle Dourado, James Maksymetz, Amanda Jacobson, Benjamin I. Laufer, Miriam Baca, Oded Foreman, David H. Hackos, Lorena Riol-Blanco, Joshua S. Kaminker (2023). Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function. Nature Communications.

Benjamin I. Laufer, Yu Hasegawa, Zhichao Zhang, Casey E. Hogrefe, Laura A. Del Rosso, Lori Haapanen, Hyeyeon Hwang, Melissa D. Bauman, Judy Van de Water, Ameer Y. Taha, Carolyn M. Slupsky, Mari S. Golub, John P. Capitanio, Catherine A. VandeVoort, Cheryl K. Walker, Janine M. LaSalle (2022). Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models. Nature Communications.

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Angela G. Maggio, Henry T. Shu, Benjamin I. Laufer, Chongfeng Bi, Yinglei Lai, Janine M. LaSalle, Valerie W. Hu (2022). Elevated exposures to persistent endocrine disrupting compounds impact the sperm methylome in regions associated with autism spectrum disorder. Frontiers in Genetics.

Shristi Pandey, Kimberle Shen, Seung-Hye Lee, Yun-An A. Shen, Yuanyuan Wang, Marcos Otero-Garcı́a, Natalya Kotova, Stephen T. Vito, Benjamin I. Laufer, Dwight F. Newton, Mitchell G. Rezzonico, Jesse E. Hanson, Joshua S. Kaminker, Christopher J. Bohlen, Tracy J. Yuen, Brad A. Friedman (2022). Disease-associated oligodendrocyte responses across neurodegenerative diseases. Cell Reports.

Benjamin I. Laufer, Kari Neier, Anthony E. Valenzuela, Dag H. Yasui, Rebecca J. Schmidt, Pamela J. Lein, Janine M. LaSalle (2022). Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure. Cell Reports.

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Yihui Zhu, J. Antonio Gomez, Benjamin I. Laufer, Charles E. Mordaunt, Julia S. Mouat, Daniela C. Soto, Megan Y. Dennis, Kelly S. Benke, Kelly M. Bakulski, John Dou, Ria Marathe, Julia M. Jianu, Logan A. Williams, Orangel J. Gutierrez Fugón, Cheryl K. Walker, Sally Ozonoff, Jason Daniels, Luke P. Grosvenor, Heather E. Volk, Jason I. Feinberg, M. Daniele Fallin, Irva Hertz-Picciotto, Rebecca J. Schmidt, Dag H. Yasui, Janine M LaSalle (2022). Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism. Genome Biology.

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Anthony P. Brown, Lucy Cai, Benjamin I. Laufer, Lisa A. Miller, Janine M. LaSalle, Hong Ji (2022). Long-term effects of wildfire smoke exposure during early life on the nasal epigenome in rhesus macaques. Environment International.

Benjamin I. Laufer, J. Antonio Gomez, Julia M. Jianu, Janine M. LaSalle (2021). Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature. Epigenetics and Chromatin.

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Bonnie Alberry, Benjamin I. Laufer, Eric Chater-Diehl, Shiva M. Singh (2021). Epigenetic Impacts of Early Life Stress in Fetal Alcohol Spectrum Disorders Shape the Neurodevelopmental Continuum. Frontiers in Molecular Neuroscience.

Benjamin I. Laufer, Hyeyeon Hwang, Julia M. Jianu, Charles E. Mordaunt, Ian F. Korf, Irva Hertz-Picciotto, Janine M. LaSalle (2020). Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in down syndrome DNA methylation profiles. Human Molecular Genetics.

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Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle (2020). Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes. Genome Medicine.

Benjamin I. Laufer, Hyeyeon Hwang, Annie Vogel Ciernia, Charles E. Mordaunt, Janine M. LaSalle (2019). Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights. Epigenetics.

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Annie Vogel Ciernia, Benjamin I. Laufer, Hyeyeon Hwang, Keith W. Dunaway, Charles E. Mordaunt, Rochelle L. Coulson, Dag H. Yasui, Janine M. LaSalle (2019). Epigenomic Convergence of Neural-Immune Risk Factors in Neurodevelopmental Disorder Cortex. Cerebral Cortex.

S. Jesse Lopez, Benjamin I. Laufer, Ulrika Beitnere, Elizabeth L. Berg, Jill L. Silverman, Henriette O'geen, David J. Segal, Janine M. LaSalle (2019). Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways. Human Molecular Genetics.

Rochelle L. Coulson, Dag H. Yasui, Keith W. Dunaway, Benjamin I. Laufer, Annie Vogel Ciernia, Yihui Zhu, Charles E. Mordaunt, Theresa S. Totah, Janine M. LaSalle (2018). Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nature Communications.

Annie Vogel Ciernia, Benjamin I. Laufer, Keith W. Dunaway, Charles E. Mordaunt, Rochelle L. Coulson, Theresa S. Totah, Danielle S. Stolzenberg, Jaime C. Frahm, Akanksha Singh-Taylor, Tallie Z. Baram, Janine M. LaSalle, Dag H. Yasui (2018). Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics.

Benjamin I. Laufer, Eric J. Chater-Diehl, Joachim Kapalanga, Shiva M. Singh (2017). Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders. Alcohol.

Eric J. Chater-Diehl, Benjamin I. Laufer, Shiva M. Singh (2017). Changes to histone modifications following prenatal alcohol exposure: An emerging picture. Alcohol.

Eric J. Chater-Diehl, Benjamin I. Laufer, Christina A. Castellani, Bonnie L. Alberry, Shiva M. Singh (2016). Alteration of gene expression, DNA methylation, and histone methylation in free radical scavenging networks in adult mouse hippocampus following fetal alcohol exposure. PLoS ONE.

Benjamin I Laufer (2016). A Long-Term Neuroepigenomic Profile of Prenatal Alcohol Exposure. Electronic Thesis and Dissertation Repository.

Benjamin I. Laufer, Shiva M. Singh (2015). Strategies for precision modulation of gene expression by epigenome editing: An overview. Epigenetics and Chromatin.

Benjamin I. Laufer, Joachim Kapalanga, Christina A. Castellani, Eric J. Diehl, Liying Yan, Shiva M. Singh (2015). Associative DNA methylation changes in children with prenatal alcohol exposure. Epigenomics.

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Christina A. Castellani, Melkaye G. Melka, Eric J. Diehl, Benjamin I. Laufer, Richard L. O'Reilly, Shiva M. Singh (2015). DNA methylation in psychosis: Insights into etiology and treatment. Epigenomics.

Christina A. Castellani, Benjamin I. Laufer, Melkaye G. Melka, Eric J. Diehl, Richard L. O'Reilly, Shiva M. Singh (2015). DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. BMC Medical Genomics.

Morgan L. Kleiber, Benjamin I. Laufer, Randa L. Stringer, Shiva M. Singh (2014). Third trimester-equivalent ethanol exposure is characterized by an acute cellular stress response and an ontogenetic disruption of genes critical for synaptic establishment and function in mice. Developmental Neuroscience.

Melkaye G. Melka, Benjamin I. Laufer, Patrick McDonald, Christina A. Castellani, Nagalingam Rajakumar, Richard O'Reilly, Shiva M. Singh (2014). The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum. Clinical Epigenetics.

Katarzyna Mantha, Benjamin I. Laufer, Shiva M. Singh (2014). Molecular changes during neurodevelopment following second-trimester binge ethanol exposure in a mouse model of fetal alcohol spectrum disorder: From immediate effects to long-term adaptation. Developmental Neuroscience.

Morgan L. Kleiber, Eric J. Diehl, Benjamin I. Laufer, Katarzyna Mantha, Aniruddho Chokroborty-Hoque, Bonnie Alberry, Shiva M. Singh (2014). Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: A model for fetal alcohol spectrum disorders. Frontiers in Genetics.

Shiva M. Singh, Benjamin I. Laufer, Joachim Kapalanga (2014). Fetal alcohol and the right to be born healthy. Frontiers in Genetics.

Benjamin I. Laufer, Eric J. Diehl, Shiva M. Singh (2013). Neurodevelopmental epigenetic etiologies: Insights from studies on mouse models of fetal alcohol spectrum disorders. Epigenomics.

Benjamin I. Laufer, Katarzyna Mantha, Morgan L. Kleiber, Eric J. Diehl, Sean M.F. Addison, Shiva M. Singh (2013). Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. DMM Disease Models and Mechanisms.

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Heike Anderson-Schmidt, Olga Beltcheva, Mariko D. Brandon, Enda M. Byrne, Eric J. Diehl, Laramie Duncan, Suzanne D. Gonzalez, Eilis Hannon, Katri Kantojärvi, Iordanis Karagiannidis, Mark Z. Kos, Eszter Kotyuk, Benjamin I. Laufer, Katarzyna Mantha, Nathaniel W. Mcgregor, Sandra Meier, Vanessa Nieratschker, Helen Spiers, Alessio Squassina, Geeta A. Thakur, Yash Tiwari, Biju Viswanath, Michael J. Way, Cybele C.P. Wong, Anne O'Shea, Lynn E. Delisi (2013). Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14-18, 2012. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.

Randa L. Stringer, Benjamin I. Laufer, Morgan L. Kleiber, Shiva M. Singh (2013). Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders. Clinical Epigenetics.

Melkaye G. Melka, Christina A. Castellani, Benjamin I. Laufer, Raj N. Rajakumar, Richard O'Reilly, Shiva M. Singh (2013). Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis. Journal of Molecular Psychiatry.

Benjamin I. Laufer, Shiva M. Singh (2012). A Macro Role for Imprinted Clusters of MicroRNAs in the Brain. MicroRNA.

Morgan L. Kleiber, Benjamin I. Laufer, Elise Wright, Eric J. Diehl, Shiva M. Singh (2012). Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders. Brain Research.