Publications

Preprints

  • Laufer, BI*., Gomez, JA*., Jianu, JM., LaSalle, JM. (2020) Stable DNMT3L Overexpression in SH-SY5Y Neurons Recreates a Facet of the Genome-Wide Down Syndrome DNA Methylation Signature. [bioRxiv]

2020

  • ​Mordaunt, CE., Jianu, JM., Laufer, BI., Zhu,Y., Dunaway, KW., Bakulski, KM., Feinberg, JI., Volk, HE., Lyall, K., Croen, LA., Newschaffer, CJ., Ozonoff, S., Hertz-Picciotto, I., Fallin, DM., Schmidt, RJ., LaSalle, JM. Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes. Genome Medicine. [PDF] [Pubmed] [bioRxiv] [EpiGenie] [Medical Xpress]
  • Laufer, BI., Hwang, H., Jianu, JM., Mordaunt, CE., Korf, IF., Hertz-Picciotto, I., LaSalle, JM. Low-Pass Whole Genome Bisulfite Sequencing of Neonatal Dried Blood Spots Identifies a Role for RUNX1 in Down Syndrome DNA Methylation Profiles. Human Molecular Genetics​[PDF] [Pubmed] [bioRxiv] [EpiGenie] [Webinar]

2019

  • Lopez, SJ., Laufer, BI., Beitnere, U., Berg, E., Silverman, JL., Segal, DJ., LaSalle, JM. Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways. Human Molecular Genetics. [PDF] [Pubmed] [biorXiv]
  • Vogel Ciernia, A*., Laufer, BI*., Hwang, H., Dunaway, KW.,  Mordaunt, CE., Coulson, RL., Yasui, DH., LaSalle, JM. Epigenomic convergence of genetic and immune risk factors in autism brain. Cerebral Cortex. [PDF] [Pubmed] [bioRxiv] [Spectrum]
  • Laufer, BI., Hwang, H., Vogel Ciernia, A., Mordaunt, CE., LaSalle, JM. Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights. Epigenetics. [PDF] [Pubmed] [bioRxiv] [EpiGenie]

2018

  • Coulson, RL., Yasui, DH., Dunaway, KW., Laufer BI., Vogel Ciernia, A., Mordaunt, CE, Totah, TS., LaSalle JM. Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nature Communications. [PDF] [Pubmed] [bioRxiv] [EpiGenie]
  • Vogel Ciernia, A*., Laufer, BI*., Dunaway, KW., Mordaunt, CE., Coulson, RL., Totah, TS., Stolzenberg, DS., Frahm, JC., Singh-Taylor, A., Baram, TZ., LaSalle, JM., Yasui, DH. Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics. [PDF] [Pubmed] [bioRxiv] [EpiGenie]

2017

  • Laufer, BI., Chater-Diehl, EJ., Kapalanga, J., and Singh, SM. Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders. Alcohol. [PDF] [Pubmed]
  • Chater-Diehl, EJ., Laufer, BI., and Singh, SM. Changes to histone modifications following prenatal alcohol exposure: An emerging picture. Alcohol. [PDF] [Pubmed]

2016

  • Chater-Diehl, EJ., Laufer, BI., Castellani, CA., Alberry, BL., Singh, SM. Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. PLOS ONE[PDF] [Pubmed] [EpiGenie]

2015

  • Laufer, BI., and Singh, SM. Strategies for precision modulation of gene expression by epigenome editing: An overview. Epigenetics & Chromatin. [PDF] [Pubmed] [EpiGenie] [EpiBeat]
  • Laufer, BI., Kapalanga, J., Castellani, CA., Diehl, EJ., Yan, L., and Singh, SM. Associative DNA methylation changes in children with prenatal alcohol exposure. Epigenomics. [PDF] [Pubmed] [EpiGenie] [EpiBeat]
  • Castellani, CA.,  Laufer, BI., Melka, MG., Diehl, EJ., O’Reilly, R., and Singh, SM. DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. BMC Medical Genomics. [PDF] [Pubmed] [EpiGenie]
  • Castellani*, CA., Melka*, MG., Diehl, EJ., Laufer, BI.,  O’Reilly, R., and Singh, SM. (2015) DNA methylation in psychosis: insights into etiology and treatment. Epigenomics. [PDF] [Pubmed]

2014

  • Singh, SM., Laufer, BI., and Kapalanga, J. (2014) Fetal alcohol and the right to be born healthy…. Frontiers in Genetics. [PDF] [Pubmed]
  • Kleiber, ML., Laufer, BI., Stringer, R., and Singh, SM. (2014) Third Trimester-Equivalent Ethanol Exposure Is Characterized by an Acute Cellular Stress Response and an Ontogenetic Disruption of Genes Critical for Synaptic Establishment and Function in Mice. Developmental Neuroscience[PDF] [Pubmed]
  • Kleiber, ML., Diehl, EJ., Laufer, BI., Mantha, K., Chokroborty-Hoque, A., Alberry, B., and Singh, SM. (2014) Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders. Frontiers in Genetics. [PDF] [Pubmed]
  • Mantha, K., Laufer, BI., and Singh, SM. (2014). Molecular changes during neurodevelopment following second-trimester binge ethanol exposure in a mouse model of fetal alcohol spectrum disorder: from immediate effects to long-term adaptation. Developmental Neuroscience. [PDF] [Pubmed]
  • Melka, MG., Laufer, BI., Castellani, CA.  Rajakumar, RN., O’Reilly, R., and Singh, SM. (2014) The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum. Clinical Epigenetics[PDF] [Pubmed] [EpiGenie]

2013

  • Laufer, BI., Diehl, EJ., and Singh, SM. (2013).  Neurodevelopmental epigenetic etiologies: insights from studies on mouse models of fetal alcohol spectrum disorders. Epigenomics. [PDF] [Pubmed]
  • Stringer, R., Laufer, BI., Kleiber, M., and Singh, SM. Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders. (2013) Clinical Epigenetics. [PDF] [Pubmed]
  • Laufer, BI., Mantha, K., Kleiber, ML., Diehl, EJ., Addison, SMF., and Singh, SM. (2013). Long lasting alterations to DNA methylation and ncRNAs may underlie the effects of fetal alcohol exposure. Disease Models & Mechanisms [PDF] [Pubmed] [Editorial Highlight] [EpiGenie] [Medical Xpress] [Qiagen] [Webinar]
  • Anderson-Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantojarvi K, Karagiannidis I, Kos MZ, Kotyuk E, Laufer BI., Mantha K, McGregor NW, Meier S, Nieratschker V, Spiers H, Squassina A, Thakur GA, Tiwari Y, Viswanath B, Way MJ, Wong CCP, O’Shea A, DeLisi LE. (2013). Selected Rapporteur Summaries From the XX World Congress of Psychiatric Genetics, Hamburg, Germany, October 14–18, 2012. American Journal of Medical Genetics Part B. [PDF] [Pubmed]
  • Melka, MG., Castellani, CA. Laufer, BI., Rajakumar, RN., O’Reilly, R., and Singh, SM. (2013) Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis. Journal of Molecular Psychiatry. [PDF] [Pubmed]

2012

  • Kleiber, ML., Laufer, BI., Wright, E., Diehl, EJ., and Singh, SM(2012). Long-term alterations to the brain transcriptome in a maternal voluntary consumption model of fetal alcohol spectrum disorders. Brain Research. [PDF] [Pubmed]
  • Laufer, BI., and Singh, S.M. (2012). A Macro Role for Imprinted Clusters of MicroRNAs in the Brain. MicroRNA. [PDF] [Pubmed]