"Epigenetics"

Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex heritability and higher prevalence in males. …
Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle
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Epigenomic Convergence of Neural-Immune Risk Factors in Neurodevelopmental Disorder Cortex
Neurodevelopmental disorders (NDDs) affect 7-14% of all children in developed countries and are one of the leading causes of lifelong …
Annie Vogel Ciernia, Benjamin I. Laufer, Hyeyeon Hwang, Keith W. Dunaway, Charles E. Mordaunt, Rochelle L. Coulson, Dag H. Yasui, Janine M. LaSalle
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Changes to histone modifications following prenatal alcohol exposure: An emerging picture
Epigenetic mechanisms are important for facilitating gene-environment interactions in many disease etiologies, including Fetal Alcohol …
Eric J. Chater-Diehl, Benjamin I. Laufer, Shiva M. Singh
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Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders
Rodent models of Fetal Alcohol Spectrum Disorders (FASD) have revealed that prenatal alcohol exposure (PAE) results in differential DNA …
Benjamin I. Laufer, Eric J. Chater-Diehl, Joachim Kapalanga, Shiva M. Singh
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Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: A model for fetal alcohol spectrum disorders
There is abundant evidence that prenatal alcohol exposure leads to a range of behavioral and cognitive impairments, categorized under …
Morgan L. Kleiber, Eric J. Diehl, Benjamin I. Laufer, Katarzyna Mantha, Aniruddho Chokroborty-Hoque, Bonnie Alberry, Shiva M. Singh
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Third trimester-equivalent ethanol exposure is characterized by an acute cellular stress response and an ontogenetic disruption of genes critical for synaptic establishment and function in mice
The developing brain is remarkably sensitive to alcohol exposure, resulting in the wide range of cognitive and neurobehavioral …
Morgan L. Kleiber, Benjamin I. Laufer, Randa L. Stringer, Shiva M. Singh
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Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis
BACKGROUND: The dopamine (DA) hypothesis of schizophrenia proposes the mental illness is caused by excessive transmission of dopamine …
Melkaye G. Melka, Christina A. Castellani, Benjamin I. Laufer, Raj N. Rajakumar, Richard O'Reilly, Shiva M. Singh
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Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders
Background: Prenatal alcohol exposure is known to result in fetal alcohol spectrum disorders, a continuum of physiological, …
Randa L. Stringer, Benjamin I. Laufer, Morgan L. Kleiber, Shiva M. Singh
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