"epigenomics"

Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature
Background: Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards …
Benjamin I. Laufer, J. Antonio Gomez, Julia M. Jianu, Janine M. LaSalle
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Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights
Down Syndrome (DS) is the most common genetic cause of intellectual disability, in which an extra copy of human chromosome 21 (HSA21) …
Benjamin I. Laufer, Hyeyeon Hwang, Annie Vogel Ciernia, Charles E. Mordaunt, Janine M. LaSalle
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Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches
Augmented maternal care during the first postnatal week promotes life-long stress resilience and improved memory compared with the …
Annie Vogel Ciernia, Benjamin I. Laufer, Keith W. Dunaway, Charles E. Mordaunt, Rochelle L. Coulson, Theresa S. Totah, Danielle S. Stolzenberg, Jaime C. Frahm, Akanksha Singh-Taylor, Tallie Z. Baram, Janine M. LaSalle, Dag H. Yasui
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Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders
Rodent models of Fetal Alcohol Spectrum Disorders (FASD) have revealed that prenatal alcohol exposure (PAE) results in differential DNA …
Benjamin I. Laufer, Eric J. Chater-Diehl, Joachim Kapalanga, Shiva M. Singh
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DNA methylation in psychosis: Insights into etiology and treatment
Evidence for involvement of DNA methylation in psychosis forms the focus of this perspective. Of interest are results from two …
Christina A. Castellani, Melkaye G. Melka, Eric J. Diehl, Benjamin I. Laufer, Richard L. O'Reilly, Shiva M. Singh
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