"Neurodevelopment"

Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex heritability and higher prevalence in males. …
Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle
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Long-term alterations to DNA methylation as a biomarker of prenatal alcohol exposure: From mouse models to human children with fetal alcohol spectrum disorders
Rodent models of Fetal Alcohol Spectrum Disorders (FASD) have revealed that prenatal alcohol exposure (PAE) results in differential DNA …
Benjamin I. Laufer, Eric J. Chater-Diehl, Joachim Kapalanga, Shiva M. Singh
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Associative DNA methylation changes in children with prenatal alcohol exposure
Aim: Prenatal alcohol exposure (PAE) can cause fetal alcohol spectrum disorders (FASD). Previously, we assessed PAE in brain tissue …
Benjamin I. Laufer, Joachim Kapalanga, Christina A. Castellani, Eric J. Diehl, Liying Yan, Shiva M. Singh
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Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: A model for fetal alcohol spectrum disorders
There is abundant evidence that prenatal alcohol exposure leads to a range of behavioral and cognitive impairments, categorized under …
Morgan L. Kleiber, Eric J. Diehl, Benjamin I. Laufer, Katarzyna Mantha, Aniruddho Chokroborty-Hoque, Bonnie Alberry, Shiva M. Singh
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Molecular changes during neurodevelopment following second-trimester binge ethanol exposure in a mouse model of fetal alcohol spectrum disorder: From immediate effects to long-term adaptation
Fetal alcohol spectrum disorder (FASD) is an umbrella term that refers to a wide range of behavioral and cognitive deficits resulting …
Katarzyna Mantha, Benjamin I. Laufer, Shiva M. Singh
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Third trimester-equivalent ethanol exposure is characterized by an acute cellular stress response and an ontogenetic disruption of genes critical for synaptic establishment and function in mice
The developing brain is remarkably sensitive to alcohol exposure, resulting in the wide range of cognitive and neurobehavioral …
Morgan L. Kleiber, Benjamin I. Laufer, Randa L. Stringer, Shiva M. Singh
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Neurodevelopmental epigenetic etiologies: Insights from studies on mouse models of fetal alcohol spectrum disorders
Benjamin I. Laufer, Eric J. Diehl, Shiva M. Singh
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Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders
Background: Prenatal alcohol exposure is known to result in fetal alcohol spectrum disorders, a continuum of physiological, …
Randa L. Stringer, Benjamin I. Laufer, Morgan L. Kleiber, Shiva M. Singh
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